Causal processes can give rise to distinctive distributions in the linguistic variables that they affect. Consequently, a secure understanding of a variable's distribution can hold a key to understanding the forces that have causally shaped it. A storied distribution in linguistics has been Zipf's law, a kind of power law. In the wake of a major debate in the sciences around power-law hypotheses and the unreliability of earlier methods of evaluating them, here we re-evaluate the distributions claimed to characterize phoneme (...) frequencies. We infer the fit of power laws and three alternative distributions to 166 Australian languages, using a maximum likelihood framework. We find evidence supporting earlier results, but also nuancing them and increasing our understanding of them. Most notably, phonemic inventories appear to have a Zipfian-like frequency structure among their most-frequent members (though perhaps also a lognormal structure) but a geometric (or exponential) structure among the least-frequent. We compare these new insights the kinds of causal processes that affect the evolution of phonemic inventories over time, and identify a potential account for why, despite there being an important role for phonetic substance in phonemic change, we could still expect inventories with highly diverse phonetic content to share similar distributions of phoneme frequencies. We conclude with priorities for future work in this promising program of research. (shrink)

The authors of this article are previous or current members of the Clinical Ethics Consultation Affairs (CECA) Committee, a standing committee of the American Society for Bioethics and Humanities (ASBH). The committee is composed of seasoned healthcare ethics consultants (HCECs), and it is charged with developing and disseminating education materials for HCECs and ethics committees. The purpose of this article is to describe the educational research and development processes behind our teaching materials, which culminated in a case studies book called (...) A Case-Based Study Guide for Addressing Patient-Centered Ethical Issues in Health Care (hereafter, the Study Guide). In this article, we also enumerate how the Study Guide could be used in teaching and learning, and we identify areas that are ripe for future work. (shrink)

Here are the 18 guidance points contained in the UNAIDS document on Ethical Considerations in HIV Preventive Vaccine Research, reproduced by kind permission of the Joint United Nations Programme on HIV/AIDS.

Cet article se fonde sur un retour d’expérience auprès d’un nouveau-né présentant une maladie invalidante, lors de ses séjours en service de néonatologie au CHU d’Amiens puis de son hospitalisation à domicile. L’équipe de soins psychiques périnataux accompagne la famille dans le cadre d’une application thérapeutique de l’observation du nourrisson selon la méthode Esther Bick. Initié à l’hôpital et se continuant au domicile, ce travail a porté sur la restauration de la fonction parentale, celle-ci permettant la construction d’une peau psychique (...) relationnelle et le déploiement d’une qualité relationnelle étonnante et particulièrement vivante. Ce travail a permis une sortie de l’enfant au domicile pour de longues périodes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Cloning without Prior Approval:A Response to Recent Disclosures of NoncomplianceRuth Macklin (bio)Editor's note: In September 1994, the Kennedy Institute of Ethics Journal published a special issue on the ethics of embryo splitting or "cloning," which included papers originally prepared for a workshop on embryo splitting sponsored by the National Advisory Board on Ethics in Reproduction (NABER) and NABER's report, Human Cloning through Embryo Splitting. The impetus for the (...) project was embryo-splitting research conducted by Drs. Jerry L. Hall, Robert J. Stillman, and others, at George Washington University and presented in October 1993 at a joint meeting of the American Fertility Society and the Canadian Fertility and Andrology Society. Media coverage at the time reported that the research had been approved by the university's formal review committees. However, it came to light in December 1994 that the researchers had not obtained approval from the university's institutional review board prior to conducting the research. Following a university investigation, the researchers were disciplined and instructed to destroy their data. The university also voluntarily forwarded the records of the incident to the Office for Protection from Research Risks at the National Institutes of Health. Dr. Hall resigned from George Washington University in September 1994.In the following postscript to her article on the ethics of embryo splitting (KIEJ, September 1994), Ruth Macklin discusses these events. The letters and memoranda that she cites were obtained from NIH through the Freedom of Information Act.My article, "Splitting Embryos on the Slippery Slope: Ethics and Public Policy" (KIEJ, September 1994), included a brief assessment of the ethics of the Hall-Stillman embryo-splitting experiment conducted at George Washington University (GWU). The article reviewed the researchers' stated purpose ("to help infertile couples by reproducing nature's ability to reproduce twins"), the features of the research itself (splitting embryos that never could become viable and with no plan to implant either the original or the split embryos), and the review procedures surrounding the experiment. I said that the researchers might be [End Page 57] faulted for not waiting until embryo research guidelines had been established at the national level; on the other hand, they surely could not fail to conform to such national guidelines when none existed.My conclusions were based on information that had been reported in the print media. Dr. Robert J. Stillman's statement that the experiment "had been approved by the university's formal review committees and peer reviewed by colleagues" was reported in the Washington Post on October 25, 1993, (Sawyer 1993). However, in light of the recent disclosure that the researchers had not obtained approval from George Washington University's IRB before proceeding with the research (Schwartz 1994), I now draw a sharply different conclusion about the ethics of the researchers' behavior.The most glaring flaw was the researchers' failure to submit a protocol to their institution's IRB in advance of embarking on the research. Following an investigation of the matter, the Office for Protection from Research Risks (OPRR) made the further determination that "the failure on the part of GWU research investigators and administrators to notify the IRB promptly about noncompliance in this research constitutes additional serious noncompliance" with research regulations (J. Thomas Puglisi, Chief of the Compliance Oversight Branch, Division of Human Subject Protections, OPRR, letter to Stephen J. Trachtenberg, President of George Washington University, 23 August 1994). Is it reasonable to suppose that these researchers were unaware of their obligations (a) to obtain prior review and approval from the IRB and (b) to notify the IRB promptly about their noncompliance? Regarding the latter item, Dr. Puglisi's letter to the President of GWU states that "the notification requirement has been a longstanding element of the GWU MPA [multiple project assurance], which should have been familiar to all members of the GWU research community." I shall concentrate on the researchers' more glaring ethical omission, failure to obtain prior review and approval from the IRB.Did either or both of these researchers contend that they were unaware of any review requirements for their research? Hall blames Stillman, Director of the Division of Reproductive Endocrinology, Fertility, and IVF Programs, for not making the requirement... (shrink)

As infancy is characterized by rapid physical growth and critical periods of development, disruptions due to illness or disease reveal vulnerability associated with this period. Spinal cord injury has devastating consequences at any age, but its onset neonatally, at birth, or within the first year of life multiplies its impact. The immediate physical and physiological consequences are obvious and immense, but the effects on the typical trajectory of development are profound. Activity-based restorative therapies capitalize on activity-dependent plasticity of the neuromuscular (...) system below the lesion and when provided to children with SCI aim to improve the child’s neuromuscular capacity, health and quality of life. This is a report of an infant with a cervical SCI at birth resulting in paralysis of leg and trunk muscles and paresis of arm and hands who was enrolled in an ABRT program at 3 years of age. After 59 sessions of ABRT, the child demonstrated significant improvements in trunk control and arm function, as well as social and emotional development. Despite the chronicity of injury and low expectations for improvement with therapeutic interventions, ABRT had a positive impact on the child’s physical capacity and provided benefits across multiple developmental domains. (shrink)

The prospect of “curing” spinal cord injury using stem cell therapy is one of the significant goals of many stem cell researchers. In this communication we consider some of the physiological implications of successful in vivo spinal cord repair and the ethical issues this potential revolutionary therapy will raise.

Mr. C is a twenty‐two‐year‐old who was flown to a level‐1 trauma center after diving headfirst into shallow water. Prior to this accident, he was in excellent health. At the scene, he had been conscious but was paralyzed and had no sensation below his neck. The emergency medical services team immobilized Mr. C's neck with a cervical collar and intubated him for airway protection before transport. As Mr. C's medical care proceeds, he expresses a desire for extubation, although it was (...) not clear that he had the capacity to make this (or any other) decision. It also was unclear whether this desire reflected his authentic wishes to be allowed to die or stemmed from feelings of discomfort and agitation. Over a period of several days, Mr. C's sedation was lightened, and the psychiatry service conducted a formal decision‐making capacity assessment. Mr. C continues to express a desire to withdraw life‐sustaining medical treatment. However, the psychiatry service is concerned that Mr. C seems to lack adequate insight into what it would mean to die.What does it mean to respect Mr. C's autonomy? (shrink)

Adenosine transport in cultured human umbilical vein endothelial cells (HUVEC) was characterized and shown to be mediated by a single facilitated diffusion mechanism. Initial rates of adenosine influx at 22 degrees C were saturable [apparent Michaelis constant, 69 +/- 10 mu M; maximum velocity (V-max), 600 +/- 70 pmol.10(6) cells(-1).s(-1)] and inhibited by nitrobenzylthioinosine (NBMPR). Formycin B had an unusually high affinity [inhibitory constant K-i), 18 +/- 4.3 mu M], whereas inosine had a low affinity (K-i, 440 +/- 68 mu (...) M) and nucleobases were without effect on adenosine influx. The number of transporters (1.2 x 10(6) sites/cell) was estimated by NBMPR equilibrium binding (apparent dissociation constant, 0.11 +/- 0.01 nM; maximum binding, 2.0 +/- 0.15 pmol/10(6) cells). In addition, we compared these endothelial cells with those obtained from cords from pregnancies complicated by diabetes (HUVEC-D), since embriopathy may occur in these conditions. HUVEC-D exhibited a 2.3-fold reduction in both the V-max for adenosine influx and the maximum number of NBMPR binding sites (260 +/- 40 pmol.10(6) cells(-1).s(-1) and 0.86 +/- 0.08 pmol/10(6) cells, respectively). However, the turnover number for each nucleoside transporter in normal and diabetic HUVEC was similar (approximate to 300 adenosine molecules/s). Adenosine metabolism at 10 mu M in HUVEC-D was modified compared with normal cells. Intracellular phosphorylation (> 90%) was the predominant pathway in normal HUVEC, whereas in HUVEC-D, substantial levels of adenine and adenosine were detected. The present results demonstrate therefore the downregulation of the NBMPR-sensitive nucleoside transporter and changes in adenosine metabolism in HUVEC from diabetic pregnancies. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Mettle of Moral Fundamentalism: A Reply to Robert Baker*Tom L. Beauchamp (bio)AbstractThis article is a reply to Robert Baker’s attempt to rebut moral fundamentalism, while grounding international bioethics in a form of contractarianism. Baker is mistaken in several of his interpretations of the alleged moral fundamentalism and findings of the Advisory Committee on Human Radiation Experiments. He also misunderstands moral fundamentalism generally and wrongly categorizes it as morally (...) bankrupt. His negotiated contract model is, in the final analysis, itself a form of the moral fundamentalism he declares bankrupt.Robert baker’s imaginative and incisive articles on international bioethics (Baker 1998a & b) are rich in history and philosophy, but they are as profoundly misguided as they are misdirected. In this comment, I will concentrate both on a pivotal interpretation and criticism that he offers of the Report of the Advisory Committee on Human Radiation Experiments (ACHRE 1996) and on his philosophical thesis that a moral fundamentalism of principles and rights is bankrupt. Baker seriously misinterprets the ACHRE report, distorts and fails to refute moral fundamentalism, and ultimately embraces a form of the very fundamentalism that he declares bankrupt. These three topics are connected in that Baker’s misconceptions of the ACHRE report launch his critique of moral fundamentalism and his mistaken understanding of moral fundamentalism drives his critique of the ACHRE report. 1 [End Page 389]Some Misunderstandings of the Human Radiation CommitteeBaker proclaims a conflict between ACHRE’s moral fundamentalism and multiculturalism. He presents this conflict as primarily a factual issue regarding whether different cultures and eras accept different moral principles—“the difference claim,” in his vernacular (Baker 1998a, pp. 208–9). This interpretation eventuates in a critique of the work of both ACHRE and Ruth Macklin:[W]hen Macklin and the Radiation Committee consider the challenge of multiculturalism, they construe this challenge, not as dispute about anthropological fact, but as a dispute about philosophical theory. More specifically, they treat any assertion of the difference claim as a form of “ethical relativism.”... They thus respond to the multiculturalist’s factual observations—even to factual observations by anthropologists—as if they were philosophical analyses.(Baker 1998a, p. 209)Baker thinks that a factual question has been fallaciously transformed into a philosophical one. However, this false dilemma is a figment of his fancy. He provides no citation to ACHRE to show that it holds this view, and for an understandable reason: This position is neither stated nor presumed in the Report. ACHRE is quite clear that relativism involves both an anthropological (I would prefer to say historical) dispute about fact and a philosophical dispute about value—and that they are not the same.The Committee and its staff proceeded as follows: They first collected a large body of historical documents and facts about the practices, policies, and values that prevailed during the period they were studying. Chapters 1 through 3 and 5 through 13, 12 of the Report’s 18 chapters, display the results of this empirical work. The Committee concluded, on this basis, that research investigators and government officials were aware of the obligations generated by universal principles. The ACHRE report specifically lists six “basic” moral principles and maintains that these principles were pervasively recognized at the time of the radiation experiments (ACHRE 1996, pp. 114ff, 124). ACHRE received testimony, conducted interviews, and compiled documents that indicated how deeply these principles were woven into the fabric of American culture at the time, so deeply that no responsible research investigator could have been unaware of them. ACHRE did not move beyond its list of six principles to a broader thesis about the (factual) universality of other principles and did not examine other cultures or periods of history; such work would [End Page 390] have exceeded ACHRE’s mandate and would have done more to obscure than to further its arguments.ACHRE also found that some government officials had attempted to hide their wrongdoing—a clear indication that these officials were aware of the relevant moral principles and knew that they should not have been treating persons as they did (ACHRE 1996, pp. 152–53; Chapman 1946). These factual findings were not armchair philosophy or empirical guesswork... (shrink)

After spinal cord injury (SCI), motoneuron death occurs at and around the level of injury which induces changes in function and organization throughout the nervous system, including cortical changes. Muscle affected by SCI may consist of both innervated (accessible to voluntary drive) and denervated (inaccessible to voluntary drive) muscle fibers. Voluntary activation measured with transcranial magnetic stimulation (VATMS) can quantify voluntary cortical/subcortical drive to muscle but is limited by technical challenges including suboptimal stimulation of target muscle relative to its antagonist. (...) The motor evoked potential (MEP) in the biceps compared to the triceps (i.e., MEP ratio) may be a key parameter in the measurement of biceps VATMS after SCI. We used paired pulse TMS, which can inhibit or facilitate MEPs, to determine whether the MEP ratio affects VATMS in individuals with tetraplegia. Ten individuals with tetraplegia following cervical SCI and ten non-impaired individuals completed single pulse and paired pulse VATMS protocols. Paired pulse stimulation was delivered at 1.5, 10, and 30 ms inter-stimulus intervals (ISI). In both the SCI and non-impaired groups, the main effect of the stimulation pulse (paired pulse compared to single pulse) on VATMS was not significant in the linear mixed-effects models. In both groups for the stimulation parameters we tested, the MEP ratio was not modulated across all effort levels and did not affect VATMS. Linearity of the voluntary moment and superimposed twitch moment relation was lower in SCI participants compared to non-impaired. Poor linearity in the SCI group limits interpretation of VATMS. Future work is needed to address methodological issues that limit clinical application of VATMS. (shrink)

Sham surgery is a controversial and rarely used component of randomised clinical trials evaluating surgical interventions. The recent use of sham surgery in trials evaluating efficacy of intracerebral fetal tissue grafts in Parkinson’s disease has highlighted the ethical concerns associated with sham surgery controls. Macklin, and Dekkers and Boer argue vigorously against use of sham surgery controls. Macklin presents a broad argument against sham surgery controls while Dekkers and Boer present a narrower argument that sham surgery is unnecessary (...) in the specific setting of fetal tissue engraftment for Parkinson’s disease. I defend sham surgery controls against both these criticisms. Appropriate clinical trial design, sometimes including sham surgery, is needed to ensure that false positive trial results do not occur and endanger public safety. Results of a completed trial of fetal tissue grafting for Parkinson’s disease are used to illustrate the potential benefits of, and problems associated with, sham surgery controls. Sham surgery controls, however, should be employed only when absolutely necessary. I suggest criteria for appropriate use of sham surgery controls. (shrink)

Bookreview of, Alberto Romele, L’expérience du verbum in corde , ou l’impuissance de l’herméneutique , 260 pp. Compte rendu de l'ouvrage d'Alberto Romele, , L’expérience du verbum in corde , ou l’impuissance de l’herméneutique , 260 pp.

Although activated spinal cord glia contribute importantly to neuropathic pain, how nerve injury activates glia remains controversial. It has recently been proposed, on the basis of genetic approaches, that toll-like receptor 4 may be a key receptor for initiating microglial activation following L5 spinal nerve injury. The present studies extend this idea pharmacologically by showing that TLR4 is key for maintaining neuropathic pain following sciatic nerve chronic constriction injury. Established neuropathic pain was reversed by intrathecally delivered TLR4 receptor antagonists derived (...) from lipopolysaccharide. Additionally, -naltrexone, -naloxone, and -naloxone, which we show here to be TLR4 antagonists in vitro on both stably transfected HEK293-TLR4 and microglial cell lines, suppressed neuropathic pain with complete reversal upon chronic infusion. Immunohistochemical analyses of spinal cords following chronic infusion revealed suppression of CCI-induced microglial activation by -naloxone and -naloxone, paralleling reversal of neuropathic pain. Together, these CCI data support the conclusion that neuron-to-glia signaling through TLR4 is important not only for initiating neuropathic pain, as suggested previously, but also for maintaining established neuropathic pain. Furthermore, these studies suggest that the novel TLR4 antagonists -naloxone and -naloxone can each fully reverse established neuropathic pain upon multi-day administration. This finding with -naloxone is of potential clinical relevance. This is because -naloxone is an antagonist that is inactive at the -opioid selective receptors on neurons that produce analgesia. Thus, these data suggest that -opioid antagonists such as -naloxone may be useful clinically to suppress glial activation, yet -opioid agonists suppress pain. (shrink)

What is the relationship between our perceptions and reality? What is the relationship between the mind and the body? These are questions with which philosophers have grappled for centuries, and they are topics of considerable contemporary debate as well. Hilary Putnam has approached the divisions between perception and reality and between mind and body with great creativity throughout his career. Now, in _The Threefold Cord: Mind, Body, and World,_ he expounds upon these issues, elucidating both the strengths and weaknesses of (...) current schools of thought. With his characteristic wit and acuity, Putnam offers refreshing solutions to some of philosophy's most vexing problems. Putnam first examines the problem of realism: is objective truth possible? He acknowledges the deep impasse between empirical and idealist approaches to this question, critiquing them both, however, by highlighting the false assumption they share, that we cannot perceive the world directly. Drawing on the work of J. L. Austin and William James, Putnam develops a subtle and creative alternative, which he calls "natural realism." The second part of the book explores the mind-body question: is the mind independent of our interactions with the physical world? Again, Putnam critically assesses two sharply antithetical contemporary approaches and finds them both lacking. _The Threefold Cord_ shows the entire mind-body debate to be miscast and draws on the later work of Wittgenstein, once more advancing original views on perception and thought and their relationship with both the body and the external world. Finally, Putnam takes up two related problems--the role of causality in human behavior and whether or not thoughts and sensations have an "existence" all their own. With Putnam's lucid prose and insightful examples, _The Threefold Cord_ loosens the Gordian knots into which philosophy has bound itself over the issue of epistemology. (shrink)

L'éternalisme, la thèse selon laquelle les entités que nous catégorisons comme étant passées, présentes et futures existent tout autant, est la meilleure approche ontologique de l'existence temporelle qui soit en accord avec les théories de la relativité restreinte et de la relativité générale. Cependant, les théories de la relativité restreinte et générale ne sont pas fondamentales si bien que plusieurs programmes de recherche tentent de trouver une théorie plus fondamentale de la gravité quantique rassemblant tous les enseignements de la physique (...) relativiste et de la physique quantique. Certaines de ces approches soutiennent que le temps n'est pas fondamental. Toutefois, si le temps n'est pas fondamental, quelles en sont les conséquences pour l'éternalisme et les débats sur l'existence dans le temps ? Premièrement, je soutiendrai que la non-fondamentalité du temps que l'on rencontre dans la théorie des cordes mène à l'éternalisme standard. Deuxièmement, je soutiendrai que la non-fondamentalité du temps rencontrée dans la gravité quantique à boucles implique l'éternalisme atemporel, à savoir une nouvelle position qui demeure fidèle à l'esprit de l'éternalisme standard. (shrink)

The establishment of a functional vascular system requires multiple complex steps throughout embryogenesis, from endothelial cell (EC) specification to vascular patterning into venous and arterial hierarchies. Following the initial assembly of ECs into a network of cord‐like structures, vascular expansion and remodeling occur rapidly through morphogenetic events including vessel sprouting, fusion, and pruning. In addition, vascular morphogenesis encompasses the process of lumen formation, critical for the transformation of cords into perfusable vascular tubes. Studies in mouse, zebrafish, frog, and human endothelial (...) cells have begun to outline the cellular and molecular requirements underlying lumen formation. Although the lumen can be generated through diverse mechanisms, the coordinated participation of multiple conserved molecules including transcription factors, small GTPases, and adhesion and polarity proteins remains a fundamental principle, leading us closer to a more thorough understanding of this complex event. (shrink)

La 4e de couverture indique : « En écrivant ce livre, j'ai essayé de réaliser simultanément deux ambitions : celle de comprendre les raisons qui ont pu faire de Gottfried Keller un des écrivains que Wittgenstein admirait le plus, et celle de préciser ce que j'ai écrit sur les relations que ce philosophe a entretenues avec la religion. Ces deux objectifs convergent car peu de questions sont aussi présentes et aussi centrales dans l'oeuvre du romancier que celle de la religion. (...) De plus, l'espèce de "révélation" que Wittgenstein a eue lorsqu'il est entré en contact avec le texte de la version tolstoïenne de l'Evangile semble avoir marqué de façon profonde sa relation avec le christianisme. Même le 7ractatus comporte des fo-mules qui ont parfois une ressemblance assez frappante avec ce que Wittgenstein avait pu lire dans l'Abrégé de l'Evangile. Pour lui, "le penseur religieux honnête est comme un danseur de corde. Il marche, en apparence, presque uniquement sur l'air. Son sol est le plus étroit qui se puisse concevoir. Et pourtant on peut réellement marcher sur lui". Ce livre est certainement l'un des plus personnels de Jacques Bouveresse. Ce qui est en jeu, ce n'est pas le jugement à porter sur les dogmes, les croyances, etc., mais le regard à porter sur la foi elle-même comme attitude face à la vie. Après Peut-on ne pas croire et Que faut-il faire de la religion, ce livre est le dernier volet d'une trilogie sur la philosophie de la religion.. ». (shrink)

Pourquoi Ludwig Wittgenstein était-il fasciné par certaines œuvres du grand écrivain suisse Gottfried Keller? Cette question a intrigué Jacques Bouveresse et le fruit de cette interrogation a donné son ouvrage Le danseur et sa corde, Wittgenstein, Tolstoï, Nietzsche, Gottfried Keller et les difficultés de la foi (Marseille, Agone, 2014). Dans l’échange qui suit, organisé en mai 2017 par la section genevoise de la Société suisse de philosophie, Jacques Bouveresse et Ruedi Imbach se penchent sur le titre de cet ouvrage, sur (...) l’intention qui a présidé à sa rédaction, mais aussi sur la critique aiguë du christianisme institutionnel, surtout dans sa version doctrinale et doctrinaire, dans certaines œuvres de Keller, ainsi que sur le fort intérêt de Wittgenstein pour ces œuvres et pour cette critique. Les deux auteurs s’accordent pour dire que le christianisme ne s’enseigne pas : il est plutôt quelque chose qui relève de la vie. (shrink)

Christophe Vendries Une musicienne et son instrument à cordes sur une stèle funéraire de Dion en Macédoine. Enfin le nablium? p. 469-502 La présence, sur une stèle de Dion d'époque impériale, de la représentation d'un instrument à cordes accompagné de sa dénomination latine permet de préciser nos connaissances à propos du nablium, souvent cité dans la littérature grecque sous le nom de νάβλα, mais dont on ne possédait jusqu'à présent aucune représentation figurée assurée. L'inscription latine qui l'accompagne suggère (...) que la défunte, louée pour son dévouement aux Muses, était vraisemblablement une musicienne de métier. Nous sommes en présence d'un cas très rare où l'inscription sert de légende pour expliquer le décor sculpté de la tombe. (shrink)

Nous sommes des êtres à la fois spirituels et corporels. Mon poids est un attribut corporel, tandis que ma capacité d'imaginer un paysage marin relève d'un attribut mental. Or, une fois admise cette dualité des attributs, comment concevoir l'interaction entre le corps et l'esprit? Face aux doctrines dualistes qui échouent à répondre à cette question, Max Kistler défend ici une variante du matérialisme réductionniste qui fait droit à la notion d'émergence : corps et esprit se logent au sein d'une hiérarchie (...) de niveaux de réalité. Les personnes - exclusivement composées, comme tout autre objet matériel, d'atomes - ont des propriétés émergentes que ne possède aucune de leurs composantes. L'auteur développe ainsi une nouvelle conception de l'émergence qui la rend compatible avec la réduction. Une personne peut penser tandis qu'aucune partie de son corps ne le peut : en ce sens, la capacité de penser émerge au niveau de la personne. Mais il est en principe possible d'expliquer cette capacité en termes des parties physiologiques de la personne. Une telle intégration dans la conception scientifique du monde ne prive notre esprit ni de réalité ni d'efficacité : lorsque je raconte ma rêverie à un ami, ma rêverie et le désir de la partager figurent parmi les causes de la vibration de mes cordes vocales..."--Page 4 of cover. (shrink)

La physique contemporaine pourrait bien nous livrer un enseignement incroyable, à savoir que l'espace et le temps n'existent pas fondamentalement. Je présenterai succinctement les ontologies suggérées par les deux principaux programmes de recherche en gravité quantique : la théorie des cordes et la gravité quantique à boucles. Je soutiendrai ensuite qu'il est fructueux de prendre les différentes conceptions ontologiques de la conscience en philosophie de l'esprit en modèles pour la construction de solutions au problème de l'émergence de l'espace-temps.

« – Écoute! Qu’est-ce qui résonne? – C’est un corps sonore. – Mais lequel? Une corde, un cuivre, ou bien mon propre corps? – Écoute : c’est une peau tendue sur une chambre d’écho, et qu’un autre frappe ou pince, te faisant résonner, selon ton timbre et à son rythme. ».

Parmi les déesses du monde mésopotamien, deux figures féminines se dégagent : les soeurs Ištar et Ereškigal. Ištar agit dans la sphère des relations amoureuses, et surtout de la bataille. Elle joue dans la guerre comme elle le ferait « avec une corde à sauter ». Ereškigal règne sur le monde des morts : elle est celle « qui n’a pas connu le jeu des jeunes filles ». Cette contribution s’appuie sur les documents écrits (hymnes, narrations mythologiques) en cunéiformes (sumérien (...) – akkadien et textes bilingues) des iie et ier millénaire av. n. è. Elle prend pour angle d’approche les relations conflictuelles entre ces grandes déesses pour mieux saisir leurs rapports respectifs au jeu : où et quand jouent-elles? À quoi et avec qui jouent-elles? Quelles sont les informations que l’on peut en tirer pour les femmes et jeunes filles humaines? Diverses problématiques sont abordées à la lumière des études de genre : celles des rapports intergénérationnels et interfamiliaux, de la définition des espaces privé-public, de la séduction et de l’érotisme. (shrink)

Pointe extrême de la métaphore, l'oxymore postule, dans le théâtre claudélien, une altérité essentielle entre l'Amant et l'Amante, entre Dieu et sa créature, altérité que ne contredirait pas cependant l'identité existentielle: l'Incarnation. Prouhèze déploie sous nos yeux la bannière divine dont le signe est, comme dans les versets de Raymond Lulle, “un homme mort”. Si la corde de l'amour est tissée à coups de languissements de soupirs et de pleurs par le poète-dramaturge, la Croix est symétriquement désignée dans ses drames (...) comme l'Arbre de Vie.Un personnage aussi étrange — car bien peu théâtral — que l'Ombre Double duSoulier de Satin résume ce paradoxe dans la mesure où la représentation qu'elle offre de la tension amoureuse crée un lien insécable entre la Terre et l'Ailleurs; l'Ombre Double témoigne de ce que l'Amant et l'Amante comme Dieu et sa créature peuvent concorder dans la béatitude sans pour autant fusionner. Autrement dit, selon Claudel, que l'homme soit à l'image de Dieu ne suffit pas à sa foi, encore faut-il qu'il ne cesse de manifester sa ressemblance à Dieu. Seule, la “métaphore vive”, c'est-à-dire la métaphore ayant gardé en mémoire les paradoxes et les tensions de l'oxymore, respecterait le mystère d'une relation où la présence croît a proportion de l'absence et fonderait cette parole sacrée et compensatoire d'une resseblance mille fois déjouée. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Two NarractsAntoine Volodine (bio)1. DögbruzDögbruz dépassa le dernier lampadaire de l'avenue et il s'arrêta pour calmer sa respiration haletante. Derrière lui, la ville semblait déserte. La nuit était tombée depuis des heures, de longues heures, un grand nombre d'heures, et, alors que cette idée prenait naissance dans l'esprit de Dögbruz, la phrase bourgeonna et devint quelque chose d'inquiétant, une réflexion qui n'appartenait pas totalement à notre monde : la (...) nuit, pensa soudain Dögbruz. Elle est tombée depuis plusieurs jours.Plusieurs jours sans soleil ni lune, sans crépuscule, plusieurs longues tranches noires de vingt-quatre heures. La noirceur n'avait connu aucune interruption.– Je... Mais qu'est-ce que... bougonna Dögbruz.L'air était tiède, le sol sous ses pieds était chaud, de temps en temps une ombre minuscule voletait en silence autour de sa tête, puis disparaissait. Un flocon charbonneux. Une mouche, pensa-t-il. Elle est épuisée ou déjà morte, pensa-t-il.– Non, non, pas ça, murmura-t-il, effrayé par ce qui faisait des allées et venues entre sa sous-conscience et sa conscience, des images et des expressions qui avaient rompu avec la logique du réel.Il avait besoin de bouger les lèvres et les cordes vocales pour les chasser, ces images et ces expressions désagréables.– Non, pas morte, cette sale bestiole, corrigea-t-il à voix basse. Très fatiguée, peut-être. Comme moi, très, très fatiguée. Mais pas encore morte. Autrement elle serait au sol. Elle ne pourrait pas voler.Comme moi, pensa-t-il. Moi aussi je suis au sol. Et, s'il y a au moins une certitude ici cette nuit, c'est que je ne vole pas.Il resta quelques minutes immobile, sans rien faire d'autre que combattre les petites intuitions délirantes qui traversaient les couches inférieures de son intelligence et montaient sans hâte, comme des bulles de méthane cherchant, dans un marécage, la surface de la vase. Il reprenait son souffle en observant l'avenue, devant et derrière lui : une vallée d'obscurité monotone, deux parois de maisons non éclairées, quelques arbres qui agonisaient sous la poussière, des palmiers en phase terminale, quatre ou cinq, dans la distance, et, pour le reste, une vilaine coulée [End Page 60] de bitume, qui donnait l'impression d'avoir pour origine le ciel sans la moindre étoile, d'une épaisseur et d'une opacité repoussantes. Les lampadaires étaient rares. À la fin de l'image, rien ne brillait. Pas d'horizon, pas de séparation entre le monde des nuages et le ruban bitumeux, les maisons noyées dans le rien, plus de différence entre la nuit du haut et la nuit du bas.Il s'aperçut soudain qu'il ne respirait plus et il s'empressa de mettre un terme à ce moment d'apnée indésirable.– Saletés de poumons de merde, jura-t-il.De nouveau, ses sacs pulmonaires se gonflaient et se dégonflaient. Certes. Mais il devait y veiller, leur donner l'ordre de s'emplir puis de se vider. Sans cesse il devait contrôler cela. Il haussa les épaules au bout d'une minute.– Tu parles d'un organisme pourri, protesta-t-il, s'adressant à lui-même, ou plutôt à on ne sait quelle divinité familière qu'il associait à son destin, une divinité camarade et, face à l'adversité, aussi impuissante que lui.Alors qu'il essayait de confier son alimentation en oxygène à des réflexes qui fonctionnaient avec réticence, il distingua au bout de l'avenue une forme que d'abord il se refusa à identifier, puis qu'il fut bien obligé de reconnaître. C'était loin, à plus de cent cinquante mètres, noyé d'obscurité, mais le doute n'était pas possible. Non, non, je ne peux pas me tromper, pensa-t-il.Un lama.L'univers ici est en noir et blanc, pensa-t-il. Aucune couleur et presque aucune nuance de gris. Mais... (shrink)

Bernat argues for a unified brain-based determination of death (UBDD), noting that it “conceptually justifies” death determination both in Donation after Circulatory Determination of Death (DCDD) a...

In lieu of an abstract, here is a brief excerpt of the content:324 BOOK REVIEWS Reading in Communion: Scripture & Ethics in Christian Life. By STEPHEN E. FowL & L. GREGORY JONES. Series: Biblical Foundations in Theology. Grand Rapids: Wm. B. Eerdmans Pub. Co., 1991. Pp. ix + 166. $13.95 (paper). This book represents the collaborative attempt of a biblical scholar and an ethicist to determine the precise sense in which scriptural texts can be taken as normative for the Christian (...) moral life. The collabora· tion is a fruitful one, its results illuminating not only the problem of method in ethics, but issues of biblical hermeneutics as well. This re· sult is not serendipitous; for the authors, the question of how one ought to live the Christian life and the question of how one ought to interpret Scripture are inextricably linked. Indeed, perhaps it would be more accurate to suggest that, on the account that Fowl and Jones supply, these are different formulations of the very same question. There is no rigid demarcation here between the hermeneutical and the ethical realm, no rigorous sorting out of issues appropriate to each field of inquiry. The authors make good on their introductory promise "to write a single text " rather than simply to generate a series of " alternating perspectives " (p. 3). In the very first chapter of the book, certain typical, even dominant, ways of construing the relationship between Scripture and ethics are briefly reviewed and then rejected. Ethics is commonly perceived as being primarily "concerned with right actions and decisions," the authors contend, while the Bible is viewed as a moral guide for the " particular decisions made by isolated individuals " (p. 5). In contrast, Fowl and Jones argue that " Scripture is primarily addressed not to individuals but to specific communities called into being by God " (p. 8). Moreover, our ethical deliberations ought not to be focused on particular decisions and the formulation of moral principles that bear on those decisions, but rather, on " issues of character and the formation of character in and through socially-embodied traditions" (p. 9). The consequences of such a general position are carefully and sen· sitively explored in this first and in subsequent chapters. The authors reject the assumption that one such consequence must be the conclusion that moral behavior is not, after all, ruled behavior, that one cannot formulate and articulate the principles that govern much of what we do. Their position entails the conclusion, rather, that such principles cannot be meaningfully detached from the communally embodied traditions that engender them. Indeed, they have meaning at all only in· sofar as the individuals describing, interpreting and employing these BOOK REVIEWS 325 principles possess the peculiar habits and beliefs characteristic of the :members of a specific community. In the analysis of any given moral situation, then, the discussion of principles will necessarily presuppose.a discussion of character, of the sorts of persons involved in the situation, their moral beliefs and capabilities. It is important to note that this discussion will often take a narrative form, precisely because the delineation of character is most readily accomplished by telling stories about persons, about their communities, their politics and practices, their interests and aspirations. Thus, moral capabilities are formed in " the friendships and prac-.tices " that constitute communal life. In asserting this, the authors defend an important but not terribly controversial claim. What is especially intriguing and insightful about their account, however, is the reIated claim that moral capabilities are also hermeneutical capabilities, that some of the patterns and habits of action acquired by living in a·Community also function as habits of interpretation. "Well-formed·character," Fowl and Jones explain, is crucial not only to "Christians'.ability to live faithfully in the various contexts within which they find themselves," but also to their " ability to read, speak and perform the word of the Lord " (p. 85). Moral virtue is, on their account, a kind of interpretive skill. (If not identical, character and interpretive skill.are, at the very least, formed in the same process, inextricably linked ;together as aspects of "practical wisdom." See page 31.) This result is especially meaningful once it becomes clear that the authors are employing a usefully broadened concept of " interpreta· tion." To interpret a scriptural text can and often... (shrink)

Humans encounter and use animals in a stunning number of ways. The nature of these animals and the justifiability or unjustifiabilitly of human uses of them are the subject matter of this volume.Philosophers have long been intrigued by animal minds and vegetarianism, but only around the last quarter of the twentieth century did a significant philosophical literature begin to be developed on both the scientific study of animals and the ethics of human uses of animals. This literature had a primary (...) focus on discussion of animal psychology, the moral status of animals, the nature and significance of species, and a number of practical problems. This Oxford Handbook is designed to capture the nature of the questions as they stand today and to propose solutions to many of the major problems. Several chapters in this volume explore matters that have never previously been examined by philosophers.The authors of the thirty-five chapters come from a diverse set of philosophical interests in the History of Philosophy, the Philosophy of Mind, the Philosophy of Biology, the Philosophy of Cognitive Science, the Philosophy of Language, Ethical Theory, and Practical Ethics. They explore many theoretical issues about animal minds and an array of practical concerns about animal products, farm animals, hunting, circuses, zoos, the entertainment industry, safety-testing on animals, the status and moral significance of species, environmental ethics, the nature and significance of the minds of animals, and so on. They also investigate what the future may be expected to bring in the way of new scientific developments and new moral problems.This book of original essays is the most comprehensive single volume ever published on animal minds and the ethics of our use of animals. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Theology of Play and the Play of Theology in Thomas AquinasDavid L. Whidden IIISTUDENTS OF THOMAS AQUINAS have argued over many issues in the last 150 years or so; in fact, it is nearly impossible to get out of the very first question of the Summa Theologiae without entering into a century-long debate about the status of sacred doctrine as an Aristotelian science. We ponder whether theology meets (...) the requirements of a scientia and argue about just how to understand the task of theology in the face of Aquinas’s concern about theology as a scientia. Part of this ongoing argument is shaped by the philosophical and epistemological needs of theologians attempting to justify their positions in an academic world driven by the secular and scientific norms of the Enlightenment. Additionally, some interest in theology as a scientia is driven by the desire to provide a philosophically acceptable alternative to secular forms of reason—thus Leo’s XIII’s promotion of Thomistic philosophy.The interest in theology as a science was shaped by the historical work of Chenu in his influential articles on the topic and then by almost every other important Thomist in the last fifty years.1 Theology as a scientia is such a pressing topic that it would almost be fair to say that Thomists have developed their own scientia of theology as a scientia. [End Page 273]Beyond the modern and, perhaps, postmodern concerns driving this interest, there are good reasons to pay attention to Aquinas on the status of theology. If we focus on theology as a scientia, it is because Aquinas invites us to do so by taking up this question in one form or another at the beginning of his major theological syntheses. We are, after all, only following his lead and pondering with him just what we are thinking about, and how we are thinking, when we think about God.Within the Thomistic corpus there is, however, a minority report with regard to the status of theology. In his prologue to his commentary on Boethius’s Hebdomads, Aquinas looks at theology in a very different way, one that can supplement our understanding of sacred doctrine in its role as both an intellectual and an affective enterprise. In this commentary Aquinas journeys into a different territory and explores theology, not as a scientia, but as a kind of play—a play that evokes delight and pleasure in the one who pursues wisdom.My approach will be first to describe Aquinas’s theology with regard to regular play—the kind of recreational activities we all engage in, whether they are physical or verbal. He takes up the question of the morality of play in several places and in a way that will inform our understanding of what he means when he describes theology as play. With this understanding of regular play in place, we will then explore theology as play, based on the supposition that there is something analogical between regular play and theology as play. I will finish with some reflections on how this might contribute to our present understanding of theological work.IWhile he scatters comments about play across his corpus and mentions it in all of his theological syntheses, Aquinas gives sustained attention to play in two places: first, in his commentary on Aristotle’s Ethics, and second, in question 168 of the Secunda secundae (in the treatise on temperance) of the Summa theologiae. From the outset one will notice that one of [End Page 274] the difficulties in thinking about play with Aquinas is that the Latin word for play, ludo, is multivalent, difficult to translate, and so can sometimes mean recreational games, sometimes word play, and sometimes making fun of or deriding someone.2 Even the context does not always make it clear exactly how Aquinas is talking about play.In these two sustained treatments of play Aquinas is concerned with two main issues: first, the purpose of play; second, the morality of games and how they can be approached virtuously—with proper order. That is, he is concerned with the why and the how of games.Aquinas pursues these issues in his commentary... (shrink)

Organ donation after the circulatory determination of death requires the permanent cessation of circulation while organ donation after the brain determination of death requires the irreversible cessation of brain functions. The unified brain-based determination of death connects the brain and circulatory death criteria for circulatory death determination in organ donation as follows: permanent cessation of systemic circulation causes permanent cessation of brain circulation which causes permanent cessation of brain perfusion which causes permanent cessation of brain function. The relevant circulation that (...) must cease in circulatory death determination is that to the brain. Eliminating brain circulation from the donor ECMO organ perfusion circuit in thoracoabdominal NRP protocols satisfies the unified brain-based determination of death but only if the complete cessation of brain circulation can be proved. Despite its medical and physiologic rationale, the unified brain-based determination of death remains inconsistent with the Uniform Determination of Death Act. (shrink)

« On ne retrouvait plus les frontières. On les traçait, disait-on, avec de longues cordes, mais chacun tirait d’un côté ou de l’autre, et la nuit, un troisième venait effacer les signes de la journée. »Vue de France, la Bosnie-Herzégovine est restée une contrée dangereuse et inquiétante. Depuis que les projecteurs médiatiques ne l’éclairent plus, son image semble s’être..

Neural complexity and brain entropy have gained greater interest in recent years. The dynamics of neural signals and their relations with information processing continue to be investigated through different measures in a variety of noteworthy studies. The BEN of spontaneous neural activity decreases during states of reduced consciousness. This evidence has been showed in primary consciousness states, such as psychedelic states, under the name of “the entropic brain hypothesis.” In this manuscript we propose an extension of this hypothesis to physiological (...) and pathological aging. We review this particular facet of the complexity of the brain, mentioning studies that have investigated BEN in primary consciousness states, and extending this view to the field of neuroaging with a focus on resting-state functional Magnetic Resonance Imaging. We first introduce historic and conceptual ideas about entropy and neural complexity, treating the mindbrain as a complex nonlinear dynamic adaptive system, in light of the free energy principle. Then, we review the studies in this field, analyzing the idea that the aim of the neurocognitive system is to maintain a dynamic state of balance between order and chaos, both in terms of dynamics of neural signals and functional connectivity. In our exploration we will review studies both on acute psychedelic states and more chronic psychotic states and traits, such as those in schizophrenia, in order to show the increase of entropy in those states. Then we extend our exploration to physiological and pathological aging, where BEN is reduced. Finally, we propose an interpretation of these results, defining a general trend of BEN in primary states and cognitive aging. (shrink)

Two problems are considered here. One relates to who has moral status, and the other relates to who has moral responsibility. The criteria for mattering morally have long been disputed, and many humans and nonhuman animals have been considered “marginal cases,” on the contested edges of moral considerability and concern. The marginalization of humans and other species is frequently the pretext for denying their rights, including the rights to health care, to reproductive freedom, and to bodily autonomy. There is broad (...) agreement across cultural and philosophical traditions about the capacities and responsibilities of moral agents. I propose an inclusive and expansive way of thinking about moral status, situating it not in the characteristics or capacities of individuals, but in the responsibilities and obligations of moral agents. Moral agents, under this view, are not privileged or entitled to special treatment but rather have responsibilities. I approach this by considering some African communitarian conceptions of moral status and moral agency. I propose that moral agency can also be more expansive and include not just individual moral agents but collective entities that have some of the traits of moral agents: power, freedom, and the capacity to recognize and act on the demands of morality and acknowledge and respect the rights of others. Expanding who and what is a moral agent correspondingly extends moral responsibility for respecting rights and fostering the conditions for the health and well-being of humans and animals onto the collective entities who uniquely have the capacity to attend to global-scale health threats such as pandemics and human-caused climate change. (shrink)

This chapter presents an opinionated account of how to understand the contributions of experience, especially with respect to the role of cognitive science, in developing and assessing metaphysical theories of reality. I develop a methodological basis for the idea that, independently of work in experimental philosophy focused on explications of concepts, contemporary metaphysical theories with a role for experiential evidence can be fruitfully connected to empirical work in psychology, especially cognitive science. My argument is not that cognitive science should replace (...) the metaphysician’s use of a priori theorizing and ordinary experience as a guide to metaphysical reality. Rather, we should enrich our perspective on a priori theorizing and ordinary experience as a guide to metaphysical reality by drawing on any relevant work in cognitive science. (shrink)

This paper tries to trace the different evolutional stages the egg of primitive chordates had to pass through to reach the complex state of the bird egg . It tries to ascribe to the evolutional stages the successive appearance of transitional particularities which characterise the egg and the ontogeny of birds.The different forms of individual development in birds are classified in 7 groups, proceeding from primitive to more advanced types. The type of Galliformes, especially of the Megapodidae, is shown to (...) be very probably the most primitive one, while the Passeriformes show the highest degree of advanced specialisation.Proceeding from the primitive stages of chordates to the more advanced stages of brids a steadily growing participation of the maternal organism in the development of the young animal is stated . Corresponding to this participation we find the young in a more and more intimate dependance of the mother — a dependance that unites the young and his parents in a “system” just as complicated as that built up by the young mammal and its mother. The comparative study allows us to trace the progressive evolution of such a system in avian phylogeny.Ce travail essaie d'établir les stades de l'évolution par lesquels l'oeuf des cordés primitifs a dû successivement passer pour atteindre l'état complexe réalisé dans l'oeuf des oiseaux . Nous essayons ici d'attribuer aux stades évolutifs l'apparition successive de particularités transitoires qui, dans leur totalité, caractérisent l'oeuf et l'ontogénèse des oiseaux.Les différentes formes de l'ontogénèse des oiseaux sont groupées en 7 catégories, allant d'un mode reconnu primitif à un autre mode évolué. Les Gallinacés, en particulier les Mégapodides, nous paraissent se rapprocher le plus du stade primitif; les Passereaux semblent représenter le stade le plus avancé.En passant des stades primitifs des cordés aux stades plus évolués des oiseaux, on constate une participation progressive de la mère à l'ontogénèse de l'espèce . De cette participation résulte une dépendance de plus en plus étroite du jeune animal — dépendance qui unit les parents et leur progéniture en un „système” supérieur dépassant l'individu seul et qui n'est pas moins complexe que celui formé par la mère et l'enfant des mammifères. L'étude comparative permet actuellement de suivre l'évolution progressive d'un tel système dans la phylogénèse des oiseaux. (shrink)

Motivated ignorance is an incentivized absence of knowledge that arises in circumstances of unequal power relations, a self-protective non-knowing which frees individuals from having to reflect on the privileges they have in virtue of membership in a dominant social group. In philosophical discussions, the term “motivated ignorance” gets used interchangeably with “willful ignorance.” In the first half of this paper, using Charles Mills’ (2007) white ignorance as the defining case, I argue that this is a mistake. A significant swath of (...) cases of motivated ignorance are non-willful, or deep, following Rik Peels (2010). But in all cases, benefits accrued to some in virtue of their social position are gained and maintained at the expense of harms to others. In the second half of this paper, I argue that these harms are what ground attributions of culpability in cases of motivated ignorance and drive the normative requirement that the subject know better, so long as the facts in question are ordinarily and easily knowable (in a sense to be specified). Willfulness is not a necessary condition for culpability, even if it is a sufficient one. (shrink)